Oxidative Alkenylation/Annulation of Benzimidates via Ruthenium(II)‐Catalyzed CH Activation to Generate 3‐Methyleneisoindolin‐1‐ones. Issue 2 (23rd December 2014)

• Record Type: Journal Article
• Authors: Li, Xing Guang; Sun, Min; Liu, Kai; Liu, Pei Nian
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 2/3(2015)
• Page Start: 395
• Page End: 399
• Publication Date: 2014-12-23
• Subjects: alkenes -- annulation -- cascade reaction -- CH activation -- ruthenium; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201400727
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A novel ruthenium‐catalyzed oxidative alkenylation/annulation cascade reaction is described for synthesizing 3‐methyleneisoindolin‐1‐ones. In the protocol, the N H imidate is applied efficiently as a directing group in ruthenium‐catalyzed CH activation, generating various 3‐methyleneisoindolin‐1‐ones with high regio‐ and stereoselectivity in moderate to good yields. Abstract :