Porous Silicon Nanodiscs for Targeted Drug Delivery. (15th December 2014)

• Record Type: Journal Article
• Authors: Alhmoud, Hashim; Delalat, Bahman; Elnathan, Roey; Cifuentes‐Rius, Anna; Chaix, Arnaud; Rogers, Mary‐Louise; Durand, Jean‐Olivier; Voelcker, Nicolas H.
• Is Part Of: Advanced functional materials. Volume 25:Number 7(2015)
• Page Start: 1137
• Page End: 1145
• Publication Date: 2014-12-15
• Subjects: anticancer -- drug delivery -- nanodiscs -- nanoparticles -- porous silicon; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201403414
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : There is a strong demand for techniques that allow the fabrication of biocompatible porous nanoparticles for drug delivery applications. In this work, a new method to fabricate size‐ and shape‐controlled porous silicon (pSi) nanodiscs is described. The process relies on a combination of colloidal lithography and metal‐assisted chemical etching. Height and diameter of the pSi nanodiscs can be easily adjusted. The nanodiscs are degradable in physiological milieu and are nontoxic to mammalian cells. In order to highlight the potential of the pSi nanodiscs in drug delivery, an in vitro investigation that involved loading of nanodiscs with the anticancer agent camptothecin and functionalization of the nanodisc periphery with an antibody that targets receptors on the surface of neuroblastoma cells is carried out. The thus‐prepared nanocarriers are found to selectively attach to and kill cancer cells. Abstract : The fabrication of disc‐shaped porous silicon nanoparticles through nanosphere lithography and metal‐assisted chemical etching is described. The presented method provides a facile approach to controlling the shape and size of the resulting porous silicon nanoparticles. The targeted delivery of an anticancer drug to cancer cells is undertaken to demonstrate the potential of these particles as drug nanocarriers.