A straightforward one-pot synthesis of bioactive N-aryl oxazolidin-2-ones via a highly efficient Fe3O4@SiO2-supported acetate-based butylimidazolium ionic liquid nanocatalyst under metal- and solvent-free conditions. Issue 16 (20th July 2017)

• Record Type: Journal Article
• Authors: Gupta, Radhika; Yadav, Manavi; Gaur, Rashmi; Arora, Gunjan; Sharma, Rakesh Kumar
• Is Part Of: Green chemistry. Volume 19:Issue 16(2017)
• Page Start: 3801
• Page End: 3812
• Publication Date: 2017-07-20
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c7gc01414g
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A supported ionic liquid-based magnetic nanocatalyst has been fabricated for the formation of pharmaceutically important N -aryl oxazolidin-2-ones. Abstract : In the present study, we report the fabrication and characterization of novel acetate-based butylimidazolium ionic liquid immobilized silica-coated magnetic nanoparticles (IL-OAc@FSMNP). The synthesized nanocomposite proves its supremacy as an environmentally benign catalyst in the reaction of aniline and its derivatives with ethylene carbonate to form bioactive N -aryl oxazolidin-2-ones under metal-, ligand-, and solvent-free conditions. The catalyst offers excellent assemblies of hydrogen-bond donors and acceptors, which activate the substrates, thereby delivering good-to-excellent product yields with a conversion and selectivity of more than 99%. Additionally, mild reaction conditions, wide substrate scope, effortless catalytic recovery and recyclability of the catalyst up to eight consecutive cycles offer the potential for scale-up in various pharmaceutical applications.