Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Brønsted acid. Issue 31 (24th July 2017)

• Record Type: Journal Article
• Authors: Li, Jianjun; Fu, Yiwei; Qin, Cong; Yu, Yang; Li, Hao; Wang, Wei
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 31(2017)
• Page Start: 6474
• Page End: 6477
• Publication Date: 2017-07-24
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob01527e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A mild and efficient asymmetric cyclization reaction catalyzed by chiral Brønsted acids has been developed for the synthesis of chiral isoquinolinonaphthyridines. Abstract : A catalytic asymmetric method for the synthesis of chiral isoquinolinonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-aldehydeazaarenes and 1, 2, 3, 4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91%) and up to 92 : 8 er.