Anticancer effects of oleuropein. (14th June 2017)

• Record Type: Journal Article
• Authors: Shamshoum, Hesham; Vlavcheski, Filip; Tsiani, Evangelia
• Is Part Of: BioFactors. Volume 43:Number 4(2017:Jul./Aug.)
• Page Start: 517
• Page End: 528
• Publication Date: 2017-06-14
• Subjects: olive tree -- oleuropein -- cancer -- proliferation -- survival -- apoptosis -- cell signaling; Vitamins -- Physiological effect -- Periodicals; Trace elements -- Physiological effect -- Periodicals; Growth factors -- Physiological effect -- Periodicals; Plant growth promoting substances -- Physiological effect -- Periodicals; Biochemistry -- Periodicals; Nutritional Physiological Phenomena -- Periodicals; Trace Elements -- metabolism -- Periodicals; Vitamins -- metabolism -- Periodicals; Molecular Biology -- Periodicals; 612.399
• DOI: 10.1002/biof.1366
• Languages: English
• ISSNs: 0951-6433

Abstract

Abstract: Cancer cells exhibit enhanced proliferation rate and a resistance to apoptosis. Epidemiological studies suggest that olive oil intake is associated with a reduced risk of cancer. Olive oil, olives, and olive leaves contain many polyphenols, including oleuropein. Recently, several studies have demonstrated that oleuropein inhibits proliferation and induces apoptosis in different cancer cell lines. In addition, anticancer effects of oleuropein have been seen in animal studies. These effects are associated with oleuropein's ability to modulate gene expression and activity of a variety of different signaling proteins that play a role in proliferation and apoptosis. This article summarizes the existing in vitro and in vivo studies focusing on the anticancer effects of oleuropein and its effects on key signaling molecules. © 2017 BioFactors, 43(4):517–528, 2017