Arylation of Azaarylmethylamines with Aryl Chlorides and a NiBr2/NIXANTPHOS‐based Catalyst. Issue 16 (12th July 2017)

• Record Type: Journal Article
• Authors: Gao, Gui; Fu, Yue; Li, Minyan; Wang, Bo; Zheng, Bing; Hou, Shicong; Walsh, Patrick J.
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 16(2017)
• Page Start: 2890
• Page End: 2894
• Publication Date: 2017-07-12
• Subjects: NIXANTPHOS -- NiBr2 -- Arylation -- Azaarylmethylamines -- Aryl Chlorides; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201700438
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A nickel‐catalyzed coupling of azaarylmethylamines with aryl chlorides has been achieved. NIXANTPHOS together with low cost NiBr2 was successfully developed and optimized to exhibit high reactivity at 2.5 mol % loading. Under optimized reaction conditions, aryl(azaaryl)methylamine products were afforded in good to excellent yields (22 examples, up to 98% yield). Abstract :