Sensitivity of spatially offset Raman spectroscopy (SORS) to subcortical bone tissue. Issue 8 (2nd May 2017)

• Record Type: Journal Article
• Authors: Feng, Guanping; Ochoa, Marien; Maher, Jason R.; Awad, Hani A.; Berger, Andrew J.
• Is Part Of: Journal of biophotonics. Volume 10:Issue 8(2017)
• Page Start: 990
• Page End: 996
• Publication Date: 2017-05-02
• Subjects: spatially offset Raman spectroscopy -- bone -- osteogenesis imperfecta; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201600317
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract: The development of spatially offset Raman spectroscopy (SORS) has enabled deep, non‐invasive chemical characterization of turbid media. Here, we use SORS to measure subcortical bone tissue and depth‐resolved biochemical variability in intact, exposed murine bones. We also apply the technique to study a mouse model of the genetic bone disorder osteogenesis imperfecta. The results suggest that SORS is more sensitive to disease‐related biochemical differences in subcortical trabecular bone and marrow than conventional Raman measurements. Abstract : The development of spatially offset Raman spectroscopy (SORS) has enabled deep, non‐invasive chemical characterization of turbid media. This study uses SORS to investigate a murine model of the genetic bone disorder osteogenesis imperfecta. The results suggest that SORS is more sensitive to disease‐related biochemical differences in subcortical trabecular bone and marrow than conventional Raman measurements.