A new N-methoxyl-carbonyl benzylisoquinoline from Litsea cubeba. Issue 9 (2nd September 2017)

• Record Type: Journal Article
• Authors: Tang, Bin; Tu, Hua; Long, Han-An; Du, Jun; Guo, Jian-Min; Liu, Hong-Jin; Hu, Xin; Yang, Li; Du, Xi
• Is Part Of: Journal of Asian natural products research. Volume 19:Issue 9(2017)
• Page Start: 941
• Page End: 945
• Publication Date: 2017-09-02
• Subjects: Lauraceae -- Litsea cubeba -- benzylisoquinoline -- X-ray diffraction -- cytotoxicity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2016.1275582
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A new benzylisoquinoline alkaloid ( )-N-methoxycarbonyl-norjuziphine (1 ) was isolated from Litsea cubeba. Its structure was identified by extensively spectroscopic techniques and confirmed by the single-crystal X-ray diffraction analysis. Compound1 showed cytotoxicity against HL-60 and MCF-7 cells, with IC50 values of 18.1 and 15.0 μM, respectively, comparable to 3.1 and 17.5 μM of the cisplatin (positive control).