Chemoenzymatic synthesis of tumor-associated antigen N3 minor octasaccharide. Issue 8 (21st November 2016)

• Record Type: Journal Article
• Authors: Han, Zhipeng; Chen, Congcong; Meng, Caicai; Gao, Tian; Peng, Peng; Chen, Xi; Wang, Fengshan; Cao, Hongzhi
• Is Part Of: Journal of carbohydrate chemistry. Volume 35:Issue 8/9(2016)
• Page Start: 412
• Page End: 422
• Publication Date: 2016-11-21
• Subjects: Chemoenzymatic synthesis -- glycosyltransferase -- human milk oligosaccharide -- N3 minor antigen; Carbohydrates -- Periodicals; 547.78
• DOI: 10.1080/07328303.2017.1315123
• Languages: English
• ISSNs: 0732-8303

Abstract

GRAPHICAL ABSTRACT: ABSTRACT: A highly efficient chemoenzymatic approach was developed for the preparative scale synthesis of complex tumor-associated antigen N3 minor octasaccharide. The success of this approach relies on the highly efficient one-pot multi-enzyme based sequential enzymatic elongation of a chemically synthesized branched tetrasaccharide core structure.