Surface enhancement of a molecularly imprinted polymer film using sacrificial silica beads for increasing l-arabitol chemosensor sensitivity and detectability. Issue 31 (27th July 2017)

• Record Type: Journal Article
• Authors: Dabrowski, Marcin; Cieplak, Maciej; Noworyta, Krzysztof; Heim, Matthias; Adamkiewicz, Witold; Kuhn, Alexander; Sharma, Piyush Sindhu; Kutner, Wlodzimierz
• Is Part Of: Journal of materials chemistry. Volume 5:Issue 31(2017)
• Page Start: 6292
• Page End: 6299
• Publication Date: 2017-07-27
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c7tb01407d
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Sacrificial silica beads, used for increasing the specific surface area of a molecularly imprinted polymer film, improve the performance of the chemosensor. Abstract : Molecular imprinting in polymers leads, among others, to synthetic receptors of high selectivity, comparable to that of their biological counterparts. Deposition of a thin non-porous molecularly imprinted polymer (MIP) film directly on a transducer surface enables fabrication of chemosensors for various health relevant biocompounds. However, the sensitivity of a chemosensor with such an MIP film as the recognition unit is limited, mostly because of slow analyte diffusion through this film. Herein, a simple procedure was developed to enhance, in a controlled way, the active surface area of anl -arabitol imprinted polymer film. For this, a macroporous MIP-(l -arabitol) film was synthesized and simultaneously deposited on a gold electrode of a quartz crystal resonator transducer by potentiodynamic electropolymerization. This large surface area film effectively enhanced analytical signals of mass changes at a quartz crystal microbalance. Hence, thel -arabitol limit of quantification was ∼16-fold better than that of the corresponding non-porous MIP film of the same mass.