Dual modal imaging agents based on chromophore-bearing DTPA analogues. Issue 61 (4th August 2017)

• Record Type: Journal Article
• Authors: Sathiyajith, CuhaWijay; Hallett, Andrew J.; Amoroso, Angelo J.; Edwards, Peter G.
• Is Part Of: RSC advances. Volume 7:Issue 61(2017)
• Page Start: 38463
• Page End: 38470
• Publication Date: 2017-08-04
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra06946d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Two new DTPA analogues, centrally (L 1 ) and terminally (L 2 ) functionalised with a 1, 8-naphthalimide chromophore, have been successfully prepared and fully characterized. Abstract : Two new DTPA analogues, centrally (L 1 ) and terminally (L 2 ) functionalised with a 1, 8-naphthalimide chromophore, have been successfully prepared and fully characterized. Their Gd(iii ) complexes have also been prepared and evaluated for their ability to act as dual modal contrast agents (MRI/OI). The highly reproducible R 1 relaxivity ofL 1 (8.10 ± 0.21 mM −1 s −1, 25 °C and 30 MHz) is markedly higher than other DTPA based contrast agents. The Gd(iii ) complexes of bothL 1 andL 2 have been evaluated as luminescence probes; the ligand based fluorescence is not quenched upon complexation.