Motion-induced change in emission (MICE) for developing fluorescent probes. (10th July 2017)

• Record Type: Journal Article
• Authors: Su, Dongdong; Teoh, Chai Lean; Wang, Lu; Liu, Xiaogang; Chang, Young-Tae
• Is Part Of: Chemical Society reviews. Volume 46:Number 16(2017)
• Page Start: 4833
• Page End: 4844
• Publication Date: 2017-07-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cs00018a
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : A new concept of motion-induced change in emission (MICE) in a single molecule for developing fluorescent probes is presented and summarized. Abstract : The need for detecting and labelling environmentally and biologically important analytes has driven considerable research efforts in developing fluorescent probes. During the sensing process, molecular motions ( i.e., molecular rotations or vibrations) of a flexible fluorescent probe can be significantly altered by its embedding micro-environment or analyte, thereby leading to substantial changes in readout signals. Motion-induced change in emission (MICE) can be utilized as an effective sensing mechanism. However, in comparison to the well-understood sensing mechanisms, such as photo-induced electron transfer (PET), intramolecular charge transfer (ICT), aggregation-induced emission (AIE) and disaggregation-induced emission (DIE), MICE has not been systematically discussed to date. In this tutorial review, we will summarize the concept and mechanisms of MICE for developing single-molecular fluorescent probes, present unique advantages of MICE based sensors, demonstrate their various applications, and discuss technical challenges in this field. We expect that this review will promote a deeper understanding of MICE and facilitate the development of novel MICE based probes.