Intracavity folding of a perylene dye affords a high-affinity complex with cucurbit[8]uril. Issue 66 (2nd August 2017)

• Record Type: Journal Article
• Authors: Aryal, Gyan H.; Assaf, Khaleel I.; Hunter, Kenneth W.; Nau, Werner M.; Huang, Liming
• Is Part Of: Chemical communications. Volume 53:Issue 66(2017)
• Page Start: 9242
• Page End: 9245
• Publication Date: 2017-08-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc03483k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We have designed a fluorescent perylene dye with two aromatic units for intracavity folding to afford a high-affinity complex with cucurbit[8]uril. The high affinity allows the complex to act as a fluorescent probe for detection of strong binding guests with nanomolar sensitivity. Abstract : A fluorescent perylene dye with two aromatic units was designed for binding to cucurbit[8]uril. The binding affinity of the complexes increased about 3 orders of magnitude compared to the dye without a secondary aromatic unit. The high affinity allows the complexes to act as fluorescent probes for detection of strong binding guests with nanomolar sensitivity.