Effect of zinc supplementation on serum antibody titers to heat shock protein 27 in patients with thalassemia major. Issue 2 (March 2014)

• Record Type: Journal Article
• Authors: Ghahramanlu, Elham; Banihashem, Abdollah; Mirhossini, Naghme-Zahra; Hosseini, Golkoo; Mostafavi-Toroghi, Hesam; Tavallaie, Shima; Meshkat, Mojtaba; Ghayour-Mobarhan, Majid; Ferns, Gordon
• Is Part Of: Hematology. Volume 19:Issue 2(2014)
• Page Start: 113
• Page End: 119
• Publication Date: 2014-03
• Subjects: HSP27 Heat-Shock Proteins -- Thalassemia -- Zinc; Blood -- Diseases -- Periodicals; Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; 616.15005
• DOI: 10.1179/1607845413Y.0000000099
• Languages: English
• ISSNs: 1024-5332

Abstract

Abstract : Objective: This current study was conducted to determine the effect of zinc supplementation on antibody titers to heat shock protein 27 (anti-HSP27) in patients with beta-thalassemia major (β-TM). Methods: This was a double-blinded placebo-controlled clinical trial conducted at Dr Sheikh Hospital (Mashhad, Iran) from 2011 to 2012. Sixty-four patients (41 females and 23 males), aged between 8 and 18 years with transfusion-dependent β-TM were randomly allocated to two age- and sex-matched groups. The zinc (case) group received 30 mg of daily zinc sulfate supplementation and the placebo (control) group received same shape and color placebo over 9 months period of the trial. Serum anti-HSP27 titers were measured at the third and ninth months of the trial, using an in-house enzyme-linked immune-absorbent assay. Result: There was a significant difference in anti-HSP27 titers, between the groups after 9 months. The baseline value of anti-HSP27 was 0.44 ± 0.15 in zinc group and were significantly decreased to 0.40 ± 0.18 after 9 months on treatment, while the baseline value of anti-HSP27 were significantly increased from 0.43 ± 0.17 to 0.44 ± 0.18 in the placebo group ( P = 0.01). Conclusion: Serum anti-HSP27 titers were significantly reduced in patients with β-TM treated with zinc supplements compared to a group treated with a placebo. It suggests that the potential antioxidant and anti-inflammatory effects of zinc supplements may account for a reduction in anti-HSP27 titers in patients with β-TM.