Reference dosimetry at the Australian Synchrotron's imaging and medical beamline using free‐air ionization chamber measurements and theoretical predictions of air kerma rate and half value layer. Issue 6 (20th May 2013)

• Record Type: Journal Article
• Authors: Crosbie, Jeffrey C.; Rogers, Peter A. W.; Stevenson, Andrew W.; Hall, Christopher J.; Lye, Jessica E.; Nordström, Terese; Midgley, Stewart M.; Lewis, Robert A.
• Is Part Of: Medical physics. Volume 40:Issue 6(2013)Part 1
• Page Start: n/a
• Page End: n/a
• Publication Date: 2013-05-20
• Subjects: Dosimetry/exposure assessment -- Therapeutic applications, including brachytherapy; biomedical measurement -- dosimetry -- electron energy loss spectra -- ion recombination -- ionisation chambers -- medical computing -- radiation therapy -- synchrocyclotrons -- wigglers -- X‐ray absorption; free air ionization chamber -- x‐ray dosimetry -- synchrotron radiation; Measuring for diagnostic purposes; Identification of persons -- Radiation therapy -- Measurement of nuclear or x‐radiation -- Digital computing or data processing equipment or methods, specially adapted for specific applications -- Tubes for determining the presence, intensity, density or energy of radiation or particles; Ionization chambers -- Copper -- Dosimetry -- Wigglers -- Photons -- Electric measurements -- X‐rays -- Radiation therapy -- X‐ray spectra -- Medical imaging; Medical physics -- Periodicals; Medical physics; Geneeskunde; Natuurkunde; Toepassingen; Biophysics; Periodicals; Periodicals; Electronic journals; 610.153
• DOI: 10.1118/1.4803675
• Languages: English
• ISSNs: 0094-2405

Abstract

Abstract : Purpose: Novel, preclinical radiotherapy modalities are being developed at synchrotrons around the world, most notably stereotactic synchrotron radiation therapy and microbeam radiotherapy at the European Synchrotron Radiation Facility in Grenoble, France. The imaging and medical beamline (IMBL) at the Australian Synchrotron has recently become available for preclinical radiotherapy and imaging research with clinical trials, a distinct possibility in the coming years. The aim of this present study was to accurately characterize the synchrotron‐generated x‐ray beam for the purposes of air kerma‐based absolute dosimetry. Methods: The authors used a theoretical model of the energy spectrum from the wiggler source and validated this model by comparing the transmission through copper absorbers (0.1–3.0 mm) against real measurements conducted at the beamline. The authors used a low energy free air ionization chamber (LEFAC) from the Australian Radiation Protection and Nuclear Safety Agency and a commercially available free air chamber (ADC‐105) for the measurements. The dimensions of these two chambers are different from one another requiring careful consideration of correction factors. Results: Measured and calculated half value layer (HVL) and air kerma rates differed by less than 3% for the LEFAC when the ion chamber readings were corrected for electron energy loss and ion recombination. The agreement between measured and predicted air kerma rates was less satisfactory for the ADC‐105 chamber, however. The LEFAC and ADC measurements produced a first half value layer of 0.405 ± 0.015 and 0.412 ± 0.016 mm Cu, respectively, compared to the theoretical prediction of 0.427 ± 0.012 mm Cu. The theoretical model based upon a spectrum calculator derived a mean beam energy of 61.4 keV with a first half value layer of approximately 30 mm in water. Conclusions: The authors showed in this study their ability to verify the predicted air kerma rate and x‐ray attenuation curve on the IMBL using a simple experimental method, namely, HVL measurements. The HVL measurements strongly supports the x‐ray beam spectrum, which in turn has a profound effect on x‐ray dosimetry.