Radical Titanocene Promoted Coupling of Epoxides and Vinyl Sulfones. Issue 3 (4th December 2014)

• Record Type: Journal Article
• Authors: Fernández‐Mateos, Alfonso; Encinas‐Madrazo, Soledad; Herrero‐Teijón, Pablo; Rubio González, Rosa
• Is Part Of: European journal of organic chemistry. Issue 3(2015)
• Page Start: 548
• Page End: 555
• Publication Date: 2014-12-04
• Subjects: Synthetic methods -- Radicals -- Titanium -- Cross‐coupling -- Epoxides -- ­Vinyl sulfones; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201403288
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A radical coupling reaction of diverse vinyl sulfones and epoxides was mediated by Cp2 TiCl (Cp = cyclopentadienyl) to provide a straightforward synthetic pathway to hydroxy sulfones. The reaction was successfully achieved by using either an excess or a catalytic amount of the Ti III reagent. The scope of the reaction was studied for several different functionalized and substituted epoxides and vinyl sulfones. Abstract : A radical coupling reaction of vinyl sulfones and epoxides was mediated by Cp2 TiCl (Cp = cyclopentadienyl) to provide straightforward synthetic access to hydroxy sulfones. The reaction was achieved by using either an excess or a catalytic amount of the Ti III reagent. The scope of the reaction was studied for several different substituted epoxides and vinyl sulfones.