Transition‐Metal‐Free Synthesis of Fluorinated Nitriles and Diaryl Ketones Through a Selective C–F Bond Functionalization Under Mild Conditions. Issue 3 (12th December 2014)

• Record Type: Journal Article
• Authors: Yang, Guang‐Hui; Liu, Ming; Li, Na; Wu, Ran; Chen, Xu; Pan, Ling‐Ling; Gao, Shang; Huang, Xing; Wang, Chen; Yu, Chuan‐Ming
• Is Part Of: European journal of organic chemistry. Issue 3(2015)
• Page Start: 616
• Page End: 624
• Publication Date: 2014-12-12
• Subjects: Synthetic methods -- Oxidation -- C–F bond functionalization -- Fluorine -- Nitriles -- Ketones; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201403354
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A highly efficient and simple procedure was developed to synthesize substituted fluorinated nitriles and diaryl ketones under mild conditions from polyfluorobenzenes and phenylacetonitriles. This coupling process was achieved by using a selective C–F bond functionalization without a transition‐metal catalyst. The reactions had good functional group tolerance and provided the products in moderate to excellent yields. Abstract : A highly efficient and simple procedure was developed to synthesize substituted fluorinated nitriles and diaryl ketones under mild conditions from polyfluorobenzenes and phenylacetonitriles. This coupling process proceeded through a selective C–F bond functionalization without the use of a transition‐metal catalyst and afforded the products in moderate to excellent yields.