Light‐Mediated Deoxygenation of Alcohols with a Dimeric Gold Catalyst. Issue 1 (12th November 2014) - McCallum, Terry
Abstract: A new protocol for the reductive deoxygenation of primary alcohols was explored. This photomediated method combines a novel approach to bromination of alcohols merged with the powerful reducing capability of [Au2 (dppm)2 ]Cl2 [dppm = 1, 1‐bis(diphenylphosphino)methane] as a photoredox catalyst. The highly efficient methods discussed are marked by the use of UVA light‐emitting diodes, which have significantly reduced reaction times and lowered setup cost. Abstract : While exploring orthogonal reactivity with [Au2 (dppm)2 ]Cl2 [dppm = 1, 1‐bis(diphenylphosphino)methane], the high‐yielding photochemical bromination of alcohols was found. The simplicity of this reaction makes it a perfect match for combining bromination with reductive dehalogenation through photoredox catalysis. The highly efficient one‐pot reductive deoxygenation protocol for primary alcohols is presented.