VNP: Interactive Visual Network Pharmacology of Diseases, Targets, and Drugs. (March 2014)

• Record Type: Journal Article
• Authors: Hu, Q‐N; Deng, Z; Tu, W; Yang, X; Meng, Z‐B; Deng, Z‐X; Liu, J
• Is Part Of: CPT: pharmacometrics & systems pharmacology. Volume 3:Number 3(2014)
• Page Start: 1
• Page End: 8
• Publication Date: 2014-03
• Subjects: Pharmacokinetics -- Periodicals; Pharmacology -- Periodicals; Pharmacokinetics; Periodicals; 615.05
• DOI: 10.1038/psp.2014.1
• Languages: English
• ISSNs: 2163-8306

Abstract

Abstract : In drug discovery, promiscuous targets, multifactorial diseases, and "dirty" drugs construct complex network relationships. Network pharmacology description and analysis not only give a systems‐level understanding of drug action and disease complexity but can also help to improve the efficiency of target selection and drug design. Visual network pharmacology (VNP) is developed to visualize network pharmacology of targets, diseases, and drugs with a graph network by using disease, target or drug names, chemical structures, or protein sequence. To our knowledge, VNP is the first free interactive VNP server that should be very helpful for systems pharmacology research. VNP is freely available athttp://cadd.whu.edu.cn/ditad/vnpsearch . CPT Pharmacometrics Syst. Pharmacol . (2014) 3, e105; doi:10.1038/psp.2014.1 ; published online 12 March 2014