Basic Concepts in Population Modeling, Simulation, and Model‐Based Drug Development: Part 3—Introduction to Pharmacodynamic Modeling Methods. (2nd January 2014)

• Record Type: Journal Article
• Authors: Upton, RN; Mould, DR
• Is Part Of: CPT: pharmacometrics & systems pharmacology. Volume 3:Number 1(2014)
• Page Start: 1
• Page End: 16
• Publication Date: 2014-01-02
• Subjects: Pharmacokinetics -- Periodicals; Pharmacology -- Periodicals; Pharmacokinetics; Periodicals; 615.05
• DOI: 10.1038/psp.2013.71
• Languages: English
• ISSNs: 2163-8306

Abstract

Abstract : Population pharmacodynamic (PD) models describe the time course of drug effects, relating exposure to response, and providing a more robust understanding of drug action than single assessments. PD models can test alternative dose regimens through simulation, allowing for informed assessment of potential dose regimens and study designs. This is the third paper in a three‐part series, providing an introduction into methods for developing and evaluating population PD models. Example files are available in theSupplementary Data . CPT Pharmacometrics Syst. Pharmacol . (2014) 3, e88; doi:10.1038/psp.2013.71 ; published online 2 January 2014