Injectable dual redox responsive diselenide‐containing poly(ethylene glycol) hydrogel. Issue 9 (6th June 2017)

• Record Type: Journal Article
• Authors: Gong, Chu; Shan, Meng; Li, Bingqiang; Wu, Guolin
• Is Part Of: Journal of biomedical materials research. Volume 105:Issue 9(2017)
• Page Start: 2451
• Page End: 2460
• Publication Date: 2017-06-06
• Subjects: injectable hydrogel -- oxidation‐responsive -- reduction‐responsive -- diselenide bonds -- poly(ethylene glycol); Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.36103
• Languages: English
• ISSNs: 1549-3296

Abstract

Abstract: An injectable dual redox responsive diselenide‐containing poly(ethylene glycol) (PEG) hydrogel was successfully developed by combining the conceptions of injectable hydrogels and dual redox responsive diselenides. In the first step, four‐armed PEG was modified with N ‐hydroxysuccinimide (NHS)‐activated esters and thereafter, crosslinked by selenocystamine crosslinkers to form injectable hydrogels via the rapid reaction between NHS‐activated esters and amino groups. The cross‐sectional morphology, mechanical properties, and crosslinking modes of hydrogels were well characterized via scanning electron microscope (SEM), rheological measurements, and Fourier transform infrared spectra, respectively. In addition, the oxidation‐ and reduction‐responsive degradation behaviors of hydrogels were observed and analyzed. The model drug, rhodamine B, was encapsulated in the hydrogel. The drug‐loaded hydrogel exhibited a dual redox responsive release profile, which was consistent with the degradation experiments. The results of all experiments indicated that the formulated injectable dual redox responsive diselenide‐containing PEG hydrogel can have potential applications in various biomedical fields such as drug delivery and stimuli‐responsive drug release. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2451–2460, 2017.