Tetrathiatriarylmethyl Radicals Conjugated to an RGD‐Peptidomimetic. Issue 36 (14th November 2014)

• Record Type: Journal Article
• Authors: Driesschaert, Benoît; Levêque, Philippe; Gallez, Bernard; Marchand‐Brynaert, Jacqueline
• Is Part Of: European journal of inorganic chemistry. Issue 36(2014)
• Page Start: 8077
• Page End: 8084
• Publication Date: 2014-11-14
• Subjects: Imaging agents -- Radicals -- EPR spectroscopy -- Peptidomimetics -- Density functional calculations; Chemistry, Inorganic -- Periodicals; Organometallic chemistry -- Periodicals; Bioinorganic chemistry -- Periodicals; Solid state chemistry -- Periodicals; 546
• DOI: 10.1002/ejoc.201403049
• Languages: English
• ISSNs: 1434-1948

Abstract

Abstract: Tetrathiatriarylmethyl (TAM) radicals are favourite spin labels for electron paramagnetic resonance imaging (EPRI). In this work, we report a straightforward synthesis of new TAM radicals bound to an Arg‐Gly‐Asp (RGD)‐peptidomimetic known to be a cell‐targeting agent. These new radicals are stable in solution, and sensitive to oxygen, and their experimental EPR data is consistent with density functional theory (DFT) calculations. Abstract : Tetrathiatriarylmethyl (TAM) radicals are favourite spin labels for electron paramagnetic resonance imaging. In this work, we report a straightforward synthesis of new TAM radicals bound to an RGD‐peptidomimetic. These new radicals are stable in solution, and sensitive to oxygen, and their experimental EPR data is consistent with DFT calculations.