The progress of inflammation and oxidative stress in patients with chronic kidney disease. (6th November 2014)

• Record Type: Journal Article
• Authors: Xu, Gaosi; Luo, Kaiping; Liu, Huixin; Huang, Tianlun; Fang, Xiangdong; Tu, Weiping
• Is Part Of: Renal failure. Volume 37:Number 1(2015)
• Page Start: 45
• Page End: 49
• Publication Date: 2014-11-06
• Subjects: Chronic kidney disease -- inflammation -- oxidative stress; Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.3109/0886022X.2014.964141
• Languages: English
• ISSNs: 0886-022X

Abstract

Abstract: Background : The variations and their correlation of inflammation and oxidative stress in chronic kidney disease (CKD) have not been thoroughly understood. Materials and methods : Biomarkers of inflammation and oxidative stress were measured in a cohort of 176 patients with CKD ranging from stage 1 to 5 and 67 healthy controls. Correlation analysis in levels between inflammation and oxidative stress was also performed with estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease (MDRD) formula. Concentrations of serum creatinine (Scr), hs-CRP (hypersensitive C reactive protein) and MDA (malondialdehyde) of these participants were measured again after 12 month follow-up. Results : In the present study, with the development of CKD, serum levels of hs-CRP, interleukin-6 (IL-6) and MDA were significantly increased, and the serum levels of SOD (superoxide dismutase) and GSH-PX (glutathione peroxidase) were significantly decreased in these participants. eGFR was inversely associated with MDA and positively with SOD and GSH-PX when adjusting for age and hypertension therapy. IL-6 and hs-CRP were positively correlated with MDA, and negatively associated with SOD and GSH-PX. Notably, after 12-month follow-up, the increase in Scr was positively associated with the increase in hs-CRP ( p < 0.01) and MDA ( p < 0.05), respectively. Conclusions : Inflammation and oxidative stress interacted with each other and played pivotal roles in the development of CKD. Variation in eGFR was parallel with the changes of oxidative stress and inflammation when CKD developing.