Design and Synthesis of 3‐Trifluoromethyl‐3H‐pyrazoles and Further Investigations of Their Transformation to 1H‐Pyrazoles. Issue 34 (27th October 2014)

• Record Type: Journal Article
• Authors: Sha, Qiang; Liu, Haixuan; Wei, Yunyang
• Is Part Of: European journal of organic chemistry. Issue 34(2014)
• Page Start: 7707
• Page End: 7715
• Publication Date: 2014-10-27
• Subjects: Cycloaddition -- Sigmatropic rearrangement -- Nitrogen heterocycles; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201403141
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: An efficient intramolecular cycloaddition strategy for the synthesis of trifluoromethyl‐substituted 3 H ‐pyrazoles was developed. Subsequently, their wide applications were demonstrated: they (1) react with dioxane by a radical process and (2) undergo [1, 5] sigmatropic rearrangements. These applications are useful as the products were obtained in high yields and with excellent regioselectivity. Abstract : The synthesis of trifluoromethyl‐substituted 3 H ‐pyrazoles by an intramolecular cycloaddition strategy is developed. Subsequently, their wide applications are demonstrated: they (1) react with dioxane by a radical process and (2) undergo [1, 5] sigmatropic rearrangements. The products are obtained in high yields and with excellent regioselectivity.