Supramolecular Control of Reactivity and Catalysis – Effective Molarities of Recognition‐Mediated Bimolecular Reactions. Issue 33 (26th August 2014)

• Record Type: Journal Article
• Authors: Di Stefano, Stefano; Cacciapaglia, Roberta; Mandolini, Luigi
• Is Part Of: European journal of organic chemistry. Issue 33(2014)
• Page Start: 7304
• Page End: 7315
• Publication Date: 2014-08-26
• Subjects: Reaction mechanisms -- Kinetics -- Intracomplex reactions -- Noncovalent interactions -- Effective molarity -- Catalytic efficiency -- Supramolecular chemistry -- Host–guest systems; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201402690
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: Reactivity data relating to bimolecular reactions of compounds featuring complementary recognition sites are critically surveyed and discussed in terms of effective molarity ( EM ) as an absolute measure of the efficiency of the intracomplex reactions. Comparison of experimentally determined EM values with idealized values estimated for strain‐free cyclizations on the basis of the number of internal rotors in the linker allowed quantification of the penalties of imperfect design in terms of entropy and strain. Abstract : Effective molarities ( EM ) of intramolecular reactions in 1:1 supramolecular complexes are critically surveyed and analyzed in terms of entropy and strain.