Effects of ICI204, 448, naloxone methiodide and levocetirizine on the scratching behavior induced by a κ-opioid antagonist, nor-BNI, in ICR mice. (3rd September 2017)

• Record Type: Journal Article
• Authors: Nakasone, Tasuku; Wakuda, Hirokazu; Sugimoto, Yumi; Kamei, Chiaki
• Is Part Of: Immunopharmacology and immunotoxicology. Volume 39:Number 5(2017:Oct.)
• Page Start: 292
• Page End: 295
• Publication Date: 2017-09-03
• Subjects: nor-BNI -- ICI204, 448 -- naloxone methiodide -- levocetirizine -- scratching behavior; Immunopharmacology -- Periodicals; Immunotoxicology -- Periodicals; Antibody-toxin conjugates -- Periodicals; Immunology -- Periodicals; 615.37
• DOI: 10.1080/08923973.2017.1354879
• Languages: English
• ISSNs: 0892-3973

Abstract

Abstract: Objective: In this study, we aimed to study the effects of ICI204, 448, naloxone methiodide and levocetirizine on the scratching behavior induced by intradermal injection of a ?-opioid antagonist, nor-binaltorphimine (nor-BNI), into the rostral back of ICR mice were investigated. Materials and methods: Male ICR mice weighing 30?35 g were used. The number of scratching episodes were counted for 60 min after i.d. injection of nor-BNI. Results: nor-BNI dose dependently increased in the number of scratching episodes in ICR mice. nor-BNI-induced scratching behavior was inhibited by not only nalfurafine but also ICI204, 448, a peripherally selective ?-opioid agonist. Naloxone and naloxone methiodide, a peripherally restricted ?-opioid antagonist, also inhibited nor-BNI-induced scratching behavior. Scratching behavior induced by nor-BNI was inhibited by chlorpheniramine as well as levocetirizine, a third-generation H1 antagonist that does not cross into the CNS. Conclusion: These results suggest that scratching behavior induced by this ?-opioid antagonist, nor-BNI, is related to not only central but also peripheral opioid and H1 receptors.