One‐Pot Synthesis of Benzene and Pyridine Derivatives via Copper‐Catalyzed Coupling Reactions. Issue 15 (29th May 2017)

• Record Type: Journal Article
• Authors: Han, Jianwei; Guo, Xin; Liu, Yafeng; Fu, Yajie; Yan, Rulong; Chen, Baohua
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 15(2017)
• Page Start: 2676
• Page End: 2681
• Publication Date: 2017-05-29
• Subjects: polysubstituted pyridine -- copper-catalyzed -- polysubstituted benzene -- acetophenones -- toluene derivatives; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201700053
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A highly efficient one‐pot synthesis of polysubstituted pyridine has been achieved through copper‐catalyzed oxidative sp 3 C−H coupling of acetophenones with toluene derivatives. Besides, the polysubstituted benzene was obtained through copper‐catalyzed coupling of acetophenones. Both of the reactions exhibited a good functional group tolerance to produce a 2, 4, 6‐triphenylpyridine or 1, 3, 5‐triarylbenzene in high yields. Compared with previous methods, these transformations allow a highly flexible and efficient preparation of substituted pyridines and benzenes. Abstract :