Hierarchical cluster analysis and chemical characterisation of Myrtus communis L. essential oil from Yemen region and its antimicrobial, antioxidant and anti-colorectal adenocarcinoma properties. Issue 18 (17th September 2017)

• Record Type: Journal Article
• Authors: Anwar, Sirajudheen; Crouch, Rebecca A.; Awadh Ali, Nasser A.; Al-Fatimi, Mohamed A.; Setzer, William N.; Wessjohann, Ludger
• Is Part Of: Natural product research. Volume 31:Issue 18(2017)
• Page Start: 2158
• Page End: 2163
• Publication Date: 2017-09-17
• Subjects: Myrtus -- essential oil -- cytotoxicity -- Yemen -- GC-MS; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1277346
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The hydrodistilled essential oil obtained from the dried leaves of Myrtus communis, collected in Yemen, was analysed by GC–MS. Forty-one compounds were identified, representing 96.3% of the total oil. The major constituents of essential oil were oxygenated monoterpenoids (87.1%), linalool (29.1%), 1, 8-cineole (18.4%), α-terpineol (10.8%), geraniol (7.3%) and linalyl acetate (7.4%). The essential oil was assessed for its antimicrobial activity using a disc diffusion assay and resulted in moderate to potent antibacterial and antifungal activities targeting mainly Bacillus subtilis, Staphylococcus aureus and Candida albicans. The oil moderately reduced the diphenylpicrylhydrazyl radical (IC50 = 4.2 μL/mL or 4.1 mg/mL). In vitro cytotoxicity evaluation against HT29 (human colonic adenocarcinoma cells) showed that the essential oil exhibited a moderate antitumor effect with IC50 of 110 ± 4 μg/mL. Hierarchical cluster analysis of M. communis has been carried out based on the chemical compositions of 99 samples reported in the literature, including Yemeni sample. Abstract :