Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study. (18th August 2017)

• Record Type: Journal Article
• Authors: Kresovich, Jacob K.; Zhang, Zhou; Fang, Fang; Zheng, Yinan; Sanchez-Guerra, Marco; Joyce, Brian T.; Zhong, Jia; Chervona, Yana; Wang, Sheng; Chang, Dou; McCracken, John P.; Díaz, Anaite; Bonzini, Matteo; Carugno, Michele; Koutrakis, Petros; Kang, Choong-Min; Bian, Shurui; Gao, Tao; Byun, Hyang-Min; Schwartz, Joel; Baccarelli, Andrea A.; Hou, Lifang
• Is Part Of: Biomarkers. Volume 22:Number 6(2017)
• Page Start: 584
• Page End: 593
• Publication Date: 2017-08-18
• Subjects: Epigenetics -- histone modifications -- blood pressure -- H3K9ac -- H3K9me3 -- H3K27me3 -- H3K36me3; Biochemical markers -- Periodicals; 610.28
• DOI: 10.1080/1354750X.2017.1347961
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Context: Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear. Objective: We examine the relationship between global histone concentrations and various markers of blood pressure. Materials and methods: Using the Beijing Truck Driver Air Pollution Study, we investigated global peripheral white blood cell histone modifications (H3K9ac, H3K9me3, H3K27me3, and H3K36me3) associations with pre- and post-work measurements of systolic (SBP) and diastolic (DBP) blood pressure, mean arterial pressure (MAP), and pulse pressure (PP) using multivariable mixed-effect models. Results: H3K9ac was negatively associated with pre-work SBP and MAP; H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP; and H3K27me3 was negatively associated with pre-work SBP. Among office workers, H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP. Among truck drivers, H3K9ac and H3K27me were negatively associated with pre-work SBP, and H3K27me3 was positively associated with post-work PP. Discussion and conclusion: Epigenome-wide H3K9ac, H3K9me3, and H3K27me3 were negatively associated with multiple pre-work blood pressure measures. These associations substantially changed during the day, suggesting an influence of daily activities. Blood-based histone modification biomarkers are potential candidates for studies requiring estimations of morning/pre-work blood pressure.