Effect of metal–metal distance in Ni(ii)-based metallo-supramolecular polymers: DNA binding and cytotoxicity. Issue 60 (2nd August 2017)

• Record Type: Journal Article
• Authors: Hossain, Md. Delwar; Rana, Utpal; Chakraborty, Chanchal; Li, Jinghua; Nagano, Reiko; Minowa, Takashi; Higuchi, Masayoshi
• Is Part Of: RSC advances. Volume 7:Issue 60(2017)
• Page Start: 38008
• Page End: 38013
• Publication Date: 2017-08-02
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra05644c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Two metallo-supramolecular polymers (polyNiL1 andpolyNiL2 ) with different metal–metal distances were synthesized via (1 : 1) complexation of the Ni salts with bis(1, 10-phenanthroline)s and their DNA binding properties and cytotoxicity were revealed. Abstract : Two Ni(ii )-based metallo-supramolecular polymers (polyNiL1 andpolyNiL2 ) with different metal–metal distances were synthesized via (1 : 1) complexation between the Ni salts with bis(1, 10-phenanthroline)s and their DNA binding properties and cytotoxicity were revealed. Short metal–metal distances (1.35 nm) inpolyNiL2 showed ∼7 times stronger DNA binding properties and remarkably higher cytotoxicity to Hela-Fucci cells than long metal–metal distances (1.95 nm) inpolyNiL1 . Enhancement of Ni polymer-induced cell killing has been observed in a cell cycle study.