Synthesis, Characterization of Some Ferrocenoyl Cysteine and Histidine Conjugates, and Their Interactions with Some Metal Ions. Issue 31 (17th September 2014)

• Record Type: Journal Article
• Authors: Han, Guo‐Cheng; Ferranco, Annaleizle; Feng, Xiao‐Zhen; Chen, Zhencheng; Kraatz, Heinz‐Bernhard
• Is Part Of: European journal of inorganic chemistry. Issue 31(2014)
• Page Start: 5337
• Page End: 5347
• Publication Date: 2014-09-17
• Subjects: Bioinorganic chemistry -- Metallo­cenes -- Cysteine -- Histidine -- Pept­ides; Chemistry, Inorganic -- Periodicals; Organometallic chemistry -- Periodicals; Bioinorganic chemistry -- Periodicals; Solid state chemistry -- Periodicals; 546
• DOI: 10.1002/ejic.201402470
• Languages: English
• ISSNs: 1434-1948

Abstract

Abstract: The synthesis and characterization of a series of 1, n ′‐disubstituted ferrocenoyl cysteine and histidine conjugates is reported. Their interaction with a range of metal ions was studied. The results show that metal coordination in His‐containing peptides involved the imidazole group. Metal coordination affects the structural properties of the ferrocene (Fc) conjugates, as judged by CD spectroscopy, and also the redox properties of the Fc group. Abstract : A series of disubstituted ferrocenoyl cysteine and histidine derivatives as well as iron–sulfur cluster analogs were synthesized. According to circular dichroism (CD) spectra, all ferrocenoyl compounds have P ‐helical conformation. Conversely, after the addition of Zn II, the configuration for ferrocene (Fc) amino acid conjugates6a and6b changed from P ‐helical to M ‐helical in the 480 nm region.