Sensing of dangerous DNA. (July 2017)

• Record Type: Journal Article
• Authors: Gasser, Stephan; Zhang, Wendy Y.L.; Tan, Nikki Yi Jie; Tripathi, Shubhita; Suter, Manuel A.; Chew, Zhi Huan; Khatoo, Muznah; Ngeow, Joanne; Cheung, Florence S.G.
• Is Part Of: Mechanisms of ageing and development. Volume 165:Part A(2017)
• Page Start: 33
• Page End: 46
• Publication Date: 2017-07
• Subjects: DNA repair -- Cancer -- DNA sensor -- Cytosolic DNA -- Innate immunity; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2016.09.001
• Languages: English
• ISSNs: 0047-6374

Abstract

Abstract: The presence of damaged and microbial DNA can pose a threat to the survival of organisms. Cells express various sensors that recognize specific aspects of such potentially dangerous DNA. Recognition of damaged or microbial DNA by sensors induces cellular processes that are important for DNA repair and inflammation. Here, we review recent evidence that the cellular response to DNA damage and microbial DNA are tightly intertwined. We also discuss insights into the parameters that enable DNA sensors to distinguish damaged and microbial DNA from DNA present in healthy cells.