Immune and inflammatory responses to DNA damage in cancer and aging. (July 2017)

• Record Type: Journal Article
• Authors: Soria-Valles, Clara; López-Soto, Alejandro; Osorio, Fernando G.; López-Otín, Carlos
• Is Part Of: Mechanisms of ageing and development. Volume 165:Part A(2017)
• Page Start: 10
• Page End: 16
• Publication Date: 2017-07
• Subjects: BER base-excision repair -- DAMP danger associated molecular pattern -- DDR DNA damage response -- DSB double-strand breaks -- DNA-PK DNA-dependent protein kinase -- HDR homology-directed repair -- HGPS Hutchinson-Gilford progeria syndrome -- ICD immunogenic cell death -- IRF interferon regulatory factor -- NER nucleotide excision repair -- NHEJ non-homologous end joining -- PRR pattern recognition receptor -- ROS reactive oxygen species -- SASP senescence-associated secretory phenotype -- TLR toll-like receptor; DNA damage response -- Immunity -- Inflammation -- Cancer -- Aging; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2016.10.004
• Languages: English
• ISSNs: 0047-6374

Abstract

Highlights: DNA damage response activates systemic compensatory mechanisms, including immune system recruitment and NF-κB-driven inflammation. Alterations in these mechanisms are related to cancer development and age-associated defects. Therapeutic strategies aimed at enhancing immune system or modulating inflammation have been successfully tested in cancer and aging experimental models. Abstract: Genome instability is a hallmark of both cancer and aging processes. Beyond cell-autonomous responses, it is known that DNA damage also elicits systemic mechanisms aimed at favoring survival and damaged cells clearance. Among these mechanisms, immune activation and NF-κB-mediated inflammation play central roles in organismal control of DNA damage. We focus herein on the different experimental evidences that have allowed gaining mechanistic insight about this relationship. We also describe the functional consequences of defective immune function in cancer development and age-related alterations. Finally, we discuss different intervention strategies based on enhancing immunity or on the modulation of the inflammatory response to improve organism homeostasis in cancer and aging.