Optimal design of nanowire field-effect troponin sensors. (1st August 2017)

• Record Type: Journal Article
• Authors: Khodadadian, Amirreza; Hosseini, Kiarash; Manzour-ol-Ajdad, Ali; Hedayati, Marjan; Kalantarinejad, Reza; Heitzinger, Clemens
• Is Part Of: Computers in biology and medicine. Volume 87(2017)
• Page Start: 46
• Page End: 56
• Publication Date: 2017-08-01
• Subjects: Silicon nanowire -- Field-effect transistor -- Biosensor -- Sensor response -- Limit of detection; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2017.05.008
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: We propose a design strategy for affinity-based biosensors using nanowires for sensing and measuring biomarker concentration in biological samples. Such sensors have been shown to have superior properties compared to conventional biosensors in terms of LOD (limit of detection), response time, cost, and size. However, there are several parameters affecting the performance of such devices that must be determined. In order to solve the design problem, we have developed a comprehensive model based on stochastic transport equations that makes it possible to optimize the sensing behavior.