Improved boundary segmentation of skin lesions in high-frequency 3D ultrasound. (1st August 2017)

• Record Type: Journal Article
• Authors: Sciolla, B.; Delachartre, P.; Cowell, L.; Dambry, T.; Guibert, B.
• Is Part Of: Computers in biology and medicine. Volume 87(2017)
• Page Start: 302
• Page End: 310
• Publication Date: 2017-08-01
• Subjects: Segmentation -- Level-set -- Curvature-driven dynamics -- Feature asymmetry -- Tumor -- Melanoma -- Basal-cell carcinoma -- Ultrasound; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2017.06.012
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: In this article, we propose a segmentation algorithm for skin lesions in 3D high-frequency ultrasound images. The segmentation is done on melanoma and Basal-cell carcinoma tumors, the most common skin cancer types, and could be used for diagnosis and surgical excision planning in a clinical context. Compared with previously proposed algorithms, which tend to underestimate the size of the lesion, we propose two new boundary terms which provide significant improvements of the accuracy. The first is a probabilistic boundary expansion (PBE) term designed to broaden the segmented area at the boundaries, which uses the feature asymmetry criterion. The second is a curvature dependent regularization (CDR), which aims at overcoming the tendency of standard regularization to shrink segmented areas. On a clinical dataset of 12 patients annotated by a dermatologist, the proposed algorithm has a comparable Dice index but increases the sensitivity by 26 % . The proposed algorithm improves the sensitivity for all lesions, and the obtained sensitivity is close to that of the intra-observer variability. Graphical abstract: Highlights: We propose a new segmentation method for Melanoma and BCC tumors in 3D HF Ultrasound. The method is validated on a dataset of 3D clinical Ultrasound images on 12 patients. The two proposed new boundary terms increase the sensitivity by 21%. A Probabilistic Boundary Expansion term is designed to broaden the segmented area. Curvature-Dependent Regularization is shown to improve the level-set segmentation.