Novel biomarkers in cancer: The whole is greater than the sum of its parts. (August 2017)

• Record Type: Journal Article
• Authors: Samatov, Timur R.; Galatenko, Vladimir V.; Block, Andreas; Shkurnikov, Maxim Yu.; Tonevitsky, Alexander G.; Schumacher, Udo
• Is Part Of: Seminars in cancer biology. Volume 45(2017)
• Page Start: 50
• Page End: 57
• Publication Date: 2017-08
• Subjects: CT computed tomography -- EMT epithelial mesenchymal transition -- FFPE formalin-fixed paraffin-embedded (tissue) -- GEO gene expression omnibus -- HUVECs human umbilical vein endothelial cells -- IFP intratumoural fluid pressure -- MRI magnetic resonance imaging -- NGS next-generation sequencing -- PET positron emission tomography -- SPECT single-photon emission computed tomography -- TCGA the cancer genome atlas; Cancer biomarkers -- Gene signatures -- Intratumoural fluid pressure -- Ex vivo drug response; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2016.09.002
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: The major issues hampering progress in the treatment of cancer patients are distant metastases and drug resistance to chemotherapy. Metastasis formation is a very complex process, and looking at gene signatures alone is not enough to get deep insight into it. This paper reviews traditional and novel approaches to identify gene signature biomarkers and intratumoural fluid pressure both as a novel way of creating predictive markers and as an obstacle to cancer therapy. Finally recently developed in vitro systems to predict the response of individual patient derived cancer explants to chemotherapy are discussed.