Identification of novel simian endogenous retroviruses that are indistinguishable from simian retrovirus (SRV) on current SRV diagnostic assays. Issue 4 (27th July 2017)

• Record Type: Journal Article
• Authors: Grant, Richard; Keele, Brandon; Kuller, LaRene; Watanabe, Robin; Perret, Alex; Smedley, Jeremy
• Is Part Of: Journal of medical primatology. Volume 46:Issue 4(2017)
• Page Start: 158
• Page End: 161
• Publication Date: 2017-07-27
• Subjects: Macaque -- PCR -- sequencing -- Specific Pathogen‐Free (SPF) -- western blot; Primates -- Periodicals; Primates -- Diseases -- Periodicals; Medicine, Experimental -- Periodicals; 616.02738
• DOI: 10.1111/jmp.12297
• Languages: English
• ISSNs: 0047-2565

Abstract

Abstract: Simian betaretroviruses include the well‐known exogenous simian retroviruses (SRV‐1 through SRV‐8), and some closely related simian endogenous retroviruses (SERV). Here, we characterized two new viral genomes, which appear to represent novel SERVs but have characteristics of both SRV and SERV highlighting the need to develop new assays providing molecular and serologic differentiation of SERV and SRV to avoid false positives.