Prognostic models for primary mediastinal (thymic) B‐cell lymphoma derived from 18‐FDG PET/CT quantitative parameters in the International Extranodal Lymphoma Study Group (IELSG) 26 study. (9th May 2017)

• Record Type: Journal Article
• Authors: Ceriani, Luca; Martelli, Maurizio; Conconi, Annarita; Zinzani, Pier L.; Ferreri, Andrés J. M.; Botto, Barbara; Stelitano, Caterina; Gotti, Manuel; Cabras, Maria G.; Rigacci, Luigi; Giovanella, Luca; Zucca, Emanuele; Johnson, Peter W. M.
• Is Part Of: British journal of haematology. Volume 178:Number 4(2017)
• Page Start: 588
• Page End: 591
• Publication Date: 2017-05-09
• Subjects: positron‐emission tomography -- positron‐emission tomography metrics -- prognostic factors -- primary mediastinal B‐cell lymphoma -- total lesion glycolysis; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.14728
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: The International Extranodal Lymphoma Study Group‐26 study evaluated the prognostic role of 18‐fluorodeoxyglucose positron‐emission tomography (PET) in primary mediastinal large B‐cell lymphoma. We assessed quantitative PET parameters at diagnosis and post‐treatment in 100 patients. The end‐of‐therapy total lesion glycolysis (TLG) was the best individual outcome predictor, but the combination of baseline TLG and end‐of‐therapy visual analysis with Deauville Score (DS) showed a better positive predictive value. A model in which baseline TLG is combined with interim DS might identify patients with shorter progression‐free survival. PET metrics combined with interim DS may allow early risk assessment and warrants further studies.