Meta‐analysis of the effect of the maternal vitamin D level on the risk of spontaneous pregnancy loss. Issue 3 (19th June 2017)

• Record Type: Journal Article
• Authors: Zhang, Heng; Huang, Zhaohui; Xiao, Limin; Jiang, Xinye; Chen, Daozhen; Wei, Yarong
• Is Part Of: International journal of gynaecology and obstetrics. Volume 138:Issue 3(2017)
• Page Start: 242
• Page End: 249
• Publication Date: 2017-06-19
• Subjects: Cohort study -- Meta‐analysis -- Pregnancy loss -- Vitamin D; Gynecology -- Periodicals; Obstetrics -- Periodicals; Electronic journals; 618
• DOI: 10.1002/ijgo.12209
• Languages: English
• ISSNs: 0020-7292

Abstract

Abstract: Background: The association between vitamin D deficiency and early spontaneous pregnancy loss (SPL) is unclear. Objectives: To assess the association of serum 25‐hydroxyvitamin D (25(OH)D) and SPL. Search strategy: Embase, PubMed, and Web of Science were searched for relevant papers published before February 20, 2016, using search terms including "vitamin D" and "pregnancy loss." Selection criteria: Case–control and cohort studies investigating the relationship of maternal serum 25(OH)D and SPL were included. Data collection and analysis: Two authors independently extracted original data from the selected papers. The DerSimonian–Laird random‐effects model was used to perform the meta‐analysis. Heterogeneity was assessed by calculating I 2 . Main results: Five studies, including 10 630 pregnant women, met the inclusion criteria. There was no significant association between a low 25(OH)D level and an increased risk of SPL. In a subgroup analysis, an extremely low 25(OH)D level (<20 ng/mL) was significantly associated with an increased risk of SPL in the first trimester (relative risk 2.24, 95% confidence interval 1.15–4.37); the heterogeneity across studies was not significant ( I 2 =0.0%, P= 0.355). Conclusions: Severe Vitamin D deficiency could be detrimental to early embryonic development and increase the risk of early SPL. Abstract : A maternal 25‐hydroxyvitamin D level of less than 20 ng/mL is associated with an increased risk of spontaneous pregnancy loss in the first trimester.