Associations of dietary and serum magnesium with serum high-sensitivity C-reactive protein in early radiographic knee osteoarthritis patients. Issue 4 (4th July 2017)

• Record Type: Journal Article
• Authors: Li, Hui; Zeng, Chao; Wei, Jie; Yang, Tuo; Gao, Shu-Guang; Luo, Wei; Li, Yu-Sheng; Xiong, Yi-Lin; Xiao, Wen-Feng; Lei, Guang-Hua
• Is Part Of: Modern rheumatology. Volume 27:Issue 4(2017)
• Page Start: 669
• Page End: 674
• Publication Date: 2017-07-04
• Subjects: High-sensitivity C-reactive protein -- Magnesium -- Osteoarthritis; Rheumatology -- Periodicals; 616.723005
• DOI: 10.1080/14397595.2016.1230296
• Languages: English
• ISSNs: 1439-7595

Abstract

Abstract: Introduction : This study aimed to examine the associations of dietary magnesium (Mg) intake and serum Mg concentration with the high-sensitivity C-reactive protein (hsCRP) level in early radiographic knee osteoarthritis (OA) patients. Methods : Multivariable logistic regression was used to test the associations of dietary and serum Mg with the serum hsCRP in early radiographic knee OA patients after adjustment of a number of potential confounding factors. Results : A total of 936 early radiographic knee OA patients were included. A significant association between dietary Mg intake and hsCRP was observed. The multivariable-adjusted odds ratio (OR) (95% CI) for elevated hsCRP (≥3.0 mg/l) in the second, third, fourth, and fifth dietary Mg intake quintile were 0.44 (95% CI: 0.24–0.82), 0.58 (95% CI: 0.31–1.10), 0.34 (95% CI: 0.15–0.77), and 0.19 (95% CI: 0.06–0.57), respectively, compared with the lowest (first) quintile, and p for trend was 0.01. A significant association between serum Mg concentration and hsCRP was observed. The multivariable-adjusted OR (95% CI) for elevated hsCRP in the second, third, fourth, and fifth serum Mg concentration quintile were 0.63 (95% CI: 0.35–1.12), 0.83 (95% CI: 0.50–1.39), 0.53 (95% CI: 0.31–0.91), and 0.46 (95% CI: 0.25–0.85), respectively, compared with the lowest quintile, and p for trend was 0.01. Conclusion : The present study indicated that both dietary and serum Mg were inversely associated with serum hsCRP in early radiographic knee OA patients.