Radiofluorination of a NHC–PF5 adduct: toward new probes for 18F PET imaging. Issue 62 (21st July 2017)

• Record Type: Journal Article
• Authors: Vabre, Boris; Chansaenpak, Kantapat; Wang, Mengzhe; Wang, Hui; Li, Zibo; Gabbaï, François P.
• Is Part Of: Chemical communications. Volume 53:Issue 62(2017)
• Page Start: 8657
• Page End: 8659
• Publication Date: 2017-07-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc04402j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An N-heterocyclic carbene-PF5 adduct has been radiofluorinated to afford an unusually stable PET probe which has been imaged in vivo . Abstract : The radiofluorination of N-heterocyclic carbene (NHC) phosphorus(v ) fluoride adducts has been investigated. The results show that the IMe-PF5 derivative (IMe = 1, 3-dimethylimidazol-2-ylidene) undergoes a Lewis acid promoted 18 F– 19 F isotopic exchange. The resulting radiofluorinated probe is remarkably resistant to hydrolysis both in vitro as well as in vivo .