Quality of harvest and role of cell dose in unrelated bone marrow transplantation: An Italian Bone Marrow Donor Registry–Gruppo Italiano Trapianto di Midollo Osseo Study. (January 2014)

• Record Type: Journal Article
• Authors: Fagioli, Franca; Quarello, Paola; Pollichieni, Simona; Lamparelli, Teresa; Berger, Massimo; Benedetti, Fabio; Barat, Veronica; Marciano, Renato; Rambaldi, Alessandro; Bacigalupo, Andrea; Sacchi, Nicoletta
• Is Part Of: Hematology. Volume 19(2014)Supplement 1
• Page Start: 1
• Page End: 9
• Publication Date: 2014-01
• Subjects: Harvest -- Cell dose -- Unrelated bone marrow transplantation -- Relapse; Blood -- Diseases -- Periodicals; Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; 616.15005
• DOI: 10.1179/1607845413Y.0000000086
• Languages: English
• ISSNs: 1024-5332

Abstract

Abstract : In this study, we investigated the factors affecting cell dose harvest and the role of cell dose on outcome. We analysed data from a cohort of 703 patients who underwent unrelated bone marrow transplantation facilitated by IBMDR in GITMO centers between 2002 and 2008. The median-infused cell doses is 3.7 × 10 8 /kg, the correlation between the nucleated cells requested from transplant centers and those harvested by collection centers was adequate. A harvested/requested cells ratio lower than 0.5 was observed only in 3% of harvests. A volume of harvested marrow higher than the median value of 1270 ml was related to a significant lower infused cell dose ( χ 2 : 44.4; P < 0.001). No patient- or donor-related variables significantly influenced the cell dose except for the recipient younger age ( χ 2 : 95.7; P < 0.001) and non-malignant diseases ( χ 2 : 33.8; P < 0.001). The cell dose resulted an independent predictor factor for a better outcome in patients affected by non-malignant disease ( P = 0.05) while early disease malignant patients receiving a lower cell dose showed a higher risk of relapse ( P = 0.05).