19F CEST imaging probes for metal ion detection. Issue 30 (25th July 2017)

• Record Type: Journal Article
• Authors: Peng, Qiaoli; Yuan, Yaping; Zhang, Huaibin; Bo, Shaowei; Li, Yu; Chen, Shizhen; Yang, Zhigang; Zhou, Xin; Jiang, Zhong-Xing
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 30(2017)
• Page Start: 6441
• Page End: 6446
• Publication Date: 2017-07-25
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob01068k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An easily available fluorinated chelator was developed as a highly sensitive 19 F iCEST MRI probe for selectively detecting metal ions. Abstract : For detecting metal ions with 19 F chemical exchange saturation transfer magnetic resonance imaging ( 19 F CEST MRI), a class of novel fluorinated chelators with diverse fluorine contents and chelation properties were conveniently synthesized on gram scales. Among them, a DTPA-derived chelator with high sensitivity and selectivity was identified as a novel 19 F CEST imaging probe for simultaneously detecting multiple metal ions.