A layer-by-layer assembled MoS2 thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules. Issue 30 (21st July 2017)

• Record Type: Journal Article
• Authors: Kim, Young-Kwan; Wang, Li-Sheng; Landis, Ryan; Kim, Chang Soo; Vachet, Richard W.; Rotello, Vincent M.
• Is Part Of: Nanoscale. Volume 9:Issue 30(2017)
• Page Start: 10854
• Page End: 10860
• Publication Date: 2017-07-21
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c7nr02949g
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : LBL assembly of liquid phase exfoliated MoS2 nanoflakes for the fabrication of a chip-based LDI-MS platform. Abstract : A chip-based platform for laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was developed by utilizing layer-by-layer (LBL) assembly of MoS2 nanoflakes and polyallylamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS2 films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS2 nanoflake film exhibits high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distribution, and its performance was further enhanced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.