A direct metal-free C2–H functionalization of quinoline N-oxides: a highly selective amination and alkylation strategy towards 2-substituted quinolines. Issue 8 (19th May 2017)

• Record Type: Journal Article
• Authors: Bi, Wen-Zhu; Sun, Kai; Qu, Chen; Chen, Xiao-Lan; Qu, Ling-Bo; Zhu, Shao-Hua; Li, Xu; Wu, Hai-Tao; Duan, Li-Kun; Zhao, Yu-Fen
• Is Part Of: Organic chemistry frontiers. Volume 4:Issue 8(2017)
• Page Start: 1595
• Page End: 1600
• Publication Date: 2017-05-19
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c7qo00311k
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An efficient one-pot methodology for C2-selective amination and alkylation of quinoline N -oxides was developed in the presence of diethyl H -phosphonate. Abstract : An efficient one-pot methodology for C2-selective amination and alkylation of quinoline N -oxides towards 2-substituted quinolines was developed, via the reaction of various quinoline N -oxides with ammonia, a large variety of primary and secondary amines, as well as active methylene compounds in the presence of diethyl H -phosphonate and K2 CO3 under metal free conditions at room temperature.