Cyclin F: A component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancer. (August 2017)

• Record Type: Journal Article
• Authors: Galper, Jasmin; Rayner, Stephanie L.; Hogan, Alison L.; Fifita, Jennifer A.; Lee, Albert; Chung, Roger S.; Blair, Ian P.; Yang, Shu
• Is Part Of: International journal of biochemistry & cell biology. Volume 89(2017)
• Page Start: 216
• Page End: 220
• Publication Date: 2017-08
• Subjects: Cyclin F -- Ubiquitin proteasome system -- E3 ubiquitin ligase -- Amyotrophic lateral sclerosis -- Cancer; Biochemistry -- Periodicals; Cytology -- Periodicals; Biochemistry -- Periodicals; Cell Biology -- Periodicals; Biochimie -- Périodiques; Cytologie -- Périodiques; Biochimie; Cytologie; Biochemistry; Cytology; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); Periodicals; 572.05
• DOI: 10.1016/j.biocel.2017.06.011
• Languages: English
• ISSNs: 1357-2725

Abstract

Highlights: Cyclin F is the substrate recognition component of an E3 ubiquitin ligase complex that mediates substrate degradation through the ubiquitin-proteasome system. Cyclin F plays a role in cell cycle regulation through selective ubiquitination or binding of cell cycle proteins. Cyclin F is involved in DNA synthesis and repair mechanisms, important in the context of genotoxic stress. Cyclin F dysfunction has been linked to cancer, amyotrophic lateral sclerosis and frontotemporal dementia. Abstract: Cyclin F, encoded by CCNF, is the substrate recognition component of the Skp1-Cul1-F-box E3 ubiquitin ligase complex, SCF cyclin F . E3 ubiquitin ligases play a key role in ubiquitin-proteasome mediated protein degradation, an essential component of protein homeostatic mechanisms within the cell. By recognising and regulating the availability of several protein substrates, SCF cyclin F plays a role in regulating various cellular processes including replication and repair of DNA and cell cycle checkpoint control. Cyclin F dysfunction has been implicated in various forms of cancer and CCNF mutations were recently linked to familial and sporadic amyotrophic lateral sclerosis and frontotemporal dementia, offering a new lead to understanding the pathogenic mechanisms underlying neurodegeneration. In this review, we evaluate the current literature on the function of cyclin F with an emphasis on its roles in cancer and neurodegeneration.