Task-dependent variability of Essential Tremor. (August 2017)

• Record Type: Journal Article
• Authors: Schuhmayer, Nicole; Weber, Corinna; Kieler, Markus; Voller, Bernhard; Pirker, Walter; Auff, Eduard; Haubenberger, Dietrich
• Is Part Of: Parkinsonism & related disorders. Volume 41(2017)
• Page Start: 79
• Page End: 85
• Publication Date: 2017-08
• Subjects: Essential Tremor -- Spiral analysis -- Accelerometry -- Neurophysiology -- Learning effect; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2017.05.018
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Introduction: In Essential Tremor (ET), tremor characteristics and the impairment caused by tremor may vary from task to task. A variability of tremor frequency between postural and kinetic tasks has been proposed in ET, suggesting either multiple central oscillating networks, or peripheral or proprioceptive feedback-mechanisms. This electrophysiological study aimed to assess tremor frequencies and amplitudes in tasks involving postural and kinetic tremor, and compare findings within and across tasks, to delineate physiological differences underlying individually affected manual tasks in ET. Methods: 40 ET patients were included in the study. Tremor was characterized clinically, as well as electrophysiologically using accelerometry and digitizing tablet tasks. Tremor amplitude measures and frequencies were extracted for tasks involving kinetic (digital spiral drawing, handwriting), as well as postural tremor. Tremor was compared between and within tasks. Results: Digital spiral tremor frequencies were significantly higher compared to postural tremor frequencies, as measured by accelerometry, with a mean difference of >2 Hz (p < 0.001). Within-task variability of repeated digital spirals revealed a significant amplitude reduction over time in both hands (p < 0.001), with an up to 32% reduction compared to the first spiral. Conclusion: ET exhibited a frequency variability, which was dependent on activation condition, suggesting neurophysiologically distinct pathways between postural and kinetic tremor. The reduction of tremor amplitudes observed in repeated digital spiral drawing may be explained by a learning effect or adaptation, and should be considered as non-random factor of variability when using spirals in ET to assess effects of interventions. Highlights: Frequencies during kinetic tremor significantly differ from postural tremor in ET. This frequency-shift is suggestive of distinct tremor generation mechanisms. ET amplitudes diminish with repeated spiral drawing, suggesting a learning effect. Tablet-PC tasks of writing and pointing are valid methods capturing tremor.