Association of low serum BDNF with depression in patients with Parkinson's disease. (August 2017)

• Record Type: Journal Article
• Authors: Wang, Yu; Liu, Hong; Du, Xiang-Dong; Zhang, Yingyang; Yin, Guangzhong; Zhang, Ben-Shu; Soares, Jair C.; Zhang, Xiang Yang
• Is Part Of: Parkinsonism & related disorders. Volume 41(2017)
• Page Start: 73
• Page End: 78
• Publication Date: 2017-08
• Subjects: Parkinson's disease -- Depression -- BDNF -- Association; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2017.05.012
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Objective: Increasing evidence shows that brain-derived neurotrophic factor (BDNF) plays a critical role in the development of depression and the mechanisms of antidepressant. Parkinson disease (PD) is associated with depression and decreased BDNF. The aim of the present study was to examine the association of BDNF with depression in PD, which has not been investigated. Methods: We recruited 96 PD patients with (n = 46) and without depression (n = 50) and 102 healthy controls and measured the serum BDNF levels in both groups. Zung Self-Rating Depression Scale (SDS) was administered for the severity of depression and Hoehn-Yahr staging scale for motor abilities in PD patients. Results: Serum BDNF levels were significantly lower in PD patients than healthy controls (p < 0.01). Also serum BDNF levels were significantly decreased in PD patients with than without depression (p < 0.01). BDNF levels were negatively associated with SDS in both PD patients with and without depression (both p < 0.01). Multiple regression analysis confirmed that in either PD with or without depression group, BDNF was an independent contributor to SDS (both p < 0.05). Conclusions: Our findings suggest that decreased serum BDNF may be involved in the pathophysiology of depression in PD patients. Highlights: We compared 97 PD patients with and without depression to 102 controls on serum BDNF. BDNF was lower in PD patients than in controls, and in those with than without depression. BDNF was inversely related to depression severity in PD patients with and without depression.