Biological effect and molecular mechanism study of biomaterials based on proteomic research. Issue 7 (July 2017)

• Record Type: Journal Article
• Authors: Zhen, Zhen; Zheng, Yufeng; Ge, Zigang; Lai, Chen; Xi, Tingfei
• Is Part Of: Journal of materials science & technology. Volume 33:Issue 7(2017:Jul.)
• Page Start: 607
• Page End: 615
• Publication Date: 2017-07
• Subjects: Proteomics -- Biomaterials -- Biological effect -- Molecular mechanism; Metals -- Periodicals; Materials science -- Periodicals; Materials science; Metals; Periodicals; 620.1105
• DOI: 10.1016/j.jmst.2017.01.001
• Languages: English
• ISSNs: 1005-0302

Abstract

Abstract: Along with the role transformation of biomaterials from bioinert substitute to regenerative inducer, the biological effect and mechanism of material-organism interaction become more important. Since most of animal tests and cellular experiments stay on the phenomenon description instead of mechanism interpretation, the development of proteomics technologies provides a golden opportunity to uncover the molecular interaction mechanism between biomaterial-organism on whole scale. This review summarizes current application of proteomics in biological effect and mechanism study of biomaterials, and discusses the development and challenges for future studies.