Endocan concentrations in postmortem serum, vitreous humor and urine in victims of lethal hypothermia. (August 2017)

• Record Type: Journal Article
• Authors: Descloux, Emilienne; Augsburger, Marc; Teresiński, Grzegorz; Hejna, Petr; Grouzmann, Eric; Scarpelli, Maria Pia; Hervet, Tania; Palmiere, Cristian
• Is Part Of: Journal of forensic and legal medicine. Volume 50(2017)
• Page Start: 39
• Page End: 43
• Publication Date: 2017-08
• Subjects: Hypothermia -- Endocan -- Endothelium -- Autopsy -- Postmortem serum -- Urine -- Vitreous humor -- Postmortem biochemistry; Medical jurisprudence -- Periodicals; Forensic sciences -- Periodicals; Forensic Medicine -- Periodicals; Médecine légale -- Périodiques; Electronic journals; 614.1
• DOI: 10.1016/j.jflm.2017.07.002
• Languages: English
• ISSNs: 1752-928X

Abstract

Abstract: Endocan is a soluble molecule secreted from vascular endothelial cells of various organs. Its exact function in humans remains to be elucidated, though it has been postulated that increased tissue expression or serum levels of this molecule may be an indicator of endothelial activation and neovascularization. In the realm of forensic pathology, studies pertaining to endothelial activation following exposure to cold exclusively focused on thrombomodulin, a transmembrane protein specific to endothelial cells. In the study herein described, endocan concentrations were determined in postmortem serum, urine and vitreous humor samples collected during autopsy in a series of cases that underwent medicolegal investigations. A total of 76 autopsy cases were selected and three study groups (hypothermia group, sepsis group and non-hypothermia/non-sepsis group) prospectively formed during the study period. The obtained results seem to indicate that exposure to cold and subsequent death is not distinguished by significant endothelial dysfunction causing enhanced endocan secretion. Highlights: Endocan is expressed and secreted by activated endothelial cells. Endothelial cell activation or dysfunction may be observed during cold exposure. Postmortem serum levels of endocan are highly increased in sepsis cases compared to hypothermia.